The level of autonomy necessary for exploration requires on-board, real-time, automatic spacecraft navigational fault tolerance. Our work enables this capability through intelligent analysis of measurements from existing navigational sensors (as opposed to additional sensors needed only for fault tolerance). We have demonstrated capabilities for thruster FDI and mass property identification using the MIT SPHERES spacecraft in 2D (air-bearing table). A flight experiment on the ISS is planned for later in FY'05. Once extended and validated, our work will provide a capability for software-only thruster-fault tolerance for thruster-controlled spacecraft with gyros-a broad class of vehicles. The on-line mass and thruster-property ID technology may benefit an even broader class of applications, as accurate mass property information can be used by spacecraft control and planning algorithms to optimize system performance (e.g., minimize fuel consumption, thruster plume impingement, camera pointing error, etc.). TRL: 6 (integrated with SPHERES and ready for deployment for ISS experiments)