I plan to submit a proposal to Exobiology program (NNH05ZDA001N-EXB) that involves computation of accurate infrared spectra of small biological building blocks (e.g. amino acids, small peptides, DNA bases), as well as their precursors and other organic molecules that may exist in the interstellar medium. The proposed studies will be performed using a new technique that allows calculation of anharmonic vibrational spectra for large polyatomic molecules. I propose to eventually create a database of spectra for a number of prebiotic molecules of interest. Such database of spectroscopic signatures should assist in the interpretation of infrared data from astronomical observations. I would like to collaborate with experimentalists in code S in order to advance this project and to obtain funds.